8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction

<div>Heart morphology and function in aged WT and <i>Ogg1</i>-KO mice. (a) Ejection fraction, (b) left ventricular posterior wall, and (c) Left ventricle internal diameter measured monthly in both WT and <i>Ogg1</i>-KO mice from 7 months of age till 12 months. 3 mice per group. (d) Haematoxylin and Eosin staining of representative heart slices of WT and <i>Ogg1</i>-KO mice at 12 months of age.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2

Figure 2: 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction 