8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction

<div>Cardiac function after transverse aortic constriction in WT and <i>Ogg1-</i>KO mice. (a) Representative heart sections stained with haematoxylin and eosin in WT and <i>Ogg1-</i>KO mice hearts to show left ventricle wall thickness and fibrosis after TAC surgery. (b) Ejection fraction, (c) heart weight-to-body weight, (d) left ventricle internal diameter, (e) left ventricle posterior wall, and (f) fibrosis score were assessed presurgery and 6 weeks post-TAC in WT and <i>Ogg1</i>-KO mice. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction 