8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction

<div>Transcriptomic profile after doxorubicin treatment in WT and <i>Ogg1</i>-KO mice. (a and b) Volcano plot showing genes that are changing after treatment with doxorubicin. The red dots are genes with fold change of <svg height="13.104pt" id="M24" style="vertical-align:-3.86785pt" version="1.1" viewbox="-0.0498162 -9.23615 51.5343 13.104" width="51.5343pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M238 0V26C174 32 166 38 166 104V712C132 700 70 683 18 677V653C81 647 87 645 87 577V104C87 38 78 32 15 26V0H238Z"></path></g><g transform="matrix(.013,0,0,-0.013,3.289,0)"><path d="M257 449C165 449 37 374 37 209C37 98 119 -12 256 -12C355 -12 473 65 473 226C473 349 381 449 257 449ZM244 416C333 416 380 320 380 204C380 67 329 21 267 21C184 21 130 115 130 241C130 354 184 416 244 416Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.919,0)"><path d="M463 437C426 431 375 425 327 422C297 440 264 449 231 449H230C153 449 51 396 51 283C51 215 94 168 139 149C123 129 91 103 51 88C50 78 53 60 62 46C75 25 100 2 136 -9C112 -28 73 -59 53 -79C38 -94 29 -113 29 -135C30 -192 91 -257 203 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(c) qPCR of <i>Col1a2</i>, <i>c-Myc</i>, and <i>Il-6</i> in cardiac fibroblasts in the heart after treatment with doxorubicin.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction 