HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation

Figure 2

Overexpression of HSPB8 relieved cognitive dysfunction in DM mice. (a) Latency to the platform during training stage in Morris water maze (MWM), mice/group, two-way repeated-measures ANOVA test followed by Tukey’s post hoc test, , , , , , , WT group vs. DM group; ^#, DM group vs. group. (b–f) The cognitive ability was detected by MWM. (b) Escape latency, (c) time in the target quadrant, (d) the representative swimming path of the mice during the MWM probe test, (e) and times across the platform. (f) There was no significant difference in swimming speed among the four groups. ( mice/group). , , , . (g) Recognition index during training and test in new object recognition (NOR) ( mice/group). , , , .

(a)

(b)

(c)

(d)

(e)

(f)

(g)