The Combination of Individual Herb of Mi-Jian-Chang-Pu Formula Exerts a Synergistic Effect in the Treatment of Ischemic Stroke in Rats

Table 1

Differential metabolites identified in serum sample between sham and model groups.

No	(min)	Exact mass	Formula	Identification	VIP	Trend	Ion mode
1	0.71	132.0808	C9H9N	3-Methylindole	1.69	↓	+
2	2.19	205.0972	C11H12N2O2	Tryptophan	1.28	↓	+
3	5.61	209.0847	C10H12N2O3	L-kynurenine	2.01	↑	+
4	0.68	164.0224	C5H8NO3S	N-acetyl cysteine	1.92	↑	+
5	2.14	134.0375	C4H7NO4	Aspartic acid	1.65	↓	+
6	0.70	147.0691	C5H10N2O3	Glutamine	2.02	↓	+
7	9.91	532.3409	C27H52NO7P	LysoPE (0 : 0/22 : 2(13z,16z)	1.74	↑	—
8	0.62	130.0425	C5H7NO3	Pyroglutamic acid	1.42	↑	+
9	16.43	381.1766	C16H30O10	1,2,10-Trihydroxydihydro-trans-linalyl oxide 7-O-beta-D-glucopyranoside	1.49	↑	—
10	2.13	147.1055	C6H14N2O2	Lysine	2.04	↑	+
11	0.66	193.0271	C6H8O7	Citric acid	1.22	↑	+
12	18.96	103.0316	C4H6O3	Acetyl acetate	1.64	↓	+
13	0.88	116.0633	C5H9NO2	Proline	1.72	↓	+
14	1.51	132.0946	C6H13NO2	Isoleucine	2	↑	+
15	18.94	118.0789	C5H11N02	Valine	1.61	↓	+
16	7.91	162.0688	C6H11NO4	2-Aminoadipic acid	1.92	↓	+
17	17.64	163.9312	C4HCl2NO2	Dichloromaleimide	2.14	↑	—
18	3.31	195.1016	C11H14O3	Butyl 4-hydroxybenzoate	1.19	↓	+
19	1.51	132.0695	C4H9N3O2	Creatine	1.92	↓	+
20	13.77	257.2402	C16H32O2	Palmitic acid	2.12	↓	+
21	7.69	201.1553	C11H22O3	3-Hydroxyundecanoic acid	1.82	↓	—
22	1.47	180.1019	C10H13NO2	Salsolinol	1.29	↓	+
23	16.4	285.2788	C18H36O2	Stearic acid	1.64	↑	+
24	0.72	177.0949	C10H12N2O	5-HT	1.85	↓	+
25	10.34	526.3538	C32H49NO5	Daphniphylline	1.18	↑	—
26	3.31	223.0601	C11H10O5	Isofraxidin	1.58	↑	+
27	7.06	225.1485	C13H20O3	Methyl jasmonate	1.18	↓	+
28	7.32	468.3163	C22H47NO7P	1-Myristoyl-2hydroxy-sn-3-phosphocholine	2.14	↓	+
29	2.362	121.0295	C7H6O2	Benzoic acid	1.38	↑	—
30	11.01	377.1871	C23H26N2O3	4R-Hydroxysolifenacin	1.29	↓	—
31	18.27	220.1191	C9H17NO5	Pantothenic acid	1.33	↑	+
32	14.43	283.1693	C19H22O2	Vedaprofen	1.78	↓	+
33	2.13	119.0629	C5H10O3	Methyl 3-hydroxybutyrate	1.47	↓	+
34	2.37	359.3083	C21H42O4	Glycerol monostcarate	2.09	↑	+
35	18.91	546.1981	C27H33NO11	Doxorubicin-semiquinone	1.94	↑	—