Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC

<div>DCC activates the axon guidance pathway and thus affects synaptic activity in hippocampal neurons. (a) Expression of DCC and axon guidance pathway-related protein PLC in hippocampal neurons. (b) ELISA was used to detect the expression of PIP<sub>2</sub> and IP<sub>3</sub> in hippocampal neurons. 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independent sample <span class="nowrap"><svg height="8.02022pt" id="M45" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg>-</span>test; comparison among multiple groups was analyzed by one-way ANOVA, followed by Tukey’s post hoc test. <svg height="13.532pt" id="M46" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 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The cell experiments were repeated three times independently.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC 