DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a

Figure 3

NBP inhibited the development of knee OA after intra-articular injection of NBP in a rat model of DMM+ACLT for 8 w. (a) Representative images of HE for cartilage destruction, safranin O-fast green for cartilage regeneration, and immunohistochemistry staining for COLII expression, respectively. (b) OARSI scores in different treatment groups (). (c) Pain response time when rats were placed onto a 55°C hot plate after the surgery (). (d) The differences in two hind limb weights after the surgery in rats (). All data are expressed as the (SD). .

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