DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a

Figure 5

Bioinformatics analysis based on network pharmacology and transcriptome sequencing result after treated with NBP. (a–c) Network pharmacology. (a) Venn diagram of NBP-OA. (b) Bubble plot of the enrichment analysis results: cell components. (c) Signaling pathways. (d–f) Transcriptome sequencing. (d) Volcano plots of differentially expressed genes in the transcriptome. (e) Gene Ontology (GO) analysis of the transcriptome of chondrocytes administrated with NBP. (f) Pathway analysis from the chondrocyte transcriptome.

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