DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a

<div>NBP regulated the PI3K/AKT/FoxO3a pathway in human OA chondrocytes. (a, b) The protein expressions of FoxO1, FoxO3a, p-FoxO3a, FoxO4, PI3K, p-PI3K, AKT, and p-AKT were determined by Western blot assay. (c–e) The mRNA levels of FoxO1, FoxO3a, and FoxO4 were measured using qRT-PCR. (f) Immunofluorescence staining of FoxO3a and ACTIN (scale bar, 20 <i>μ</i>m). 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a 