DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a

<div>NBP inhibited apoptosis of human OA chondrocytes by upregulating FoxO3a. (a) Cluster analysis of mRNA levels of downstream genes in the FoxO pathway. (b, c) The mRNA levels Bcl-2 and Bax were determined. (d) The protein expressions of Bcl-2, Bax, and Caspase 3 were determined. 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Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a 