Oxidative Medicine and Cellular Longevity

Research Article

Erythropoietin Resistance Development in Hemodialysis Patients: The Role of Oxidative Stress

Table 1

Parameters of oxidative stress and resistance to short-acting erythropoietin: epoetin-α/epoetin-β.
Measured parametersERI (IU/kg/week/gHb) Value
<1.0 IU/kg/gHb≥1.0 IU/kg/gHb
NonresistantResistant
O2-. (nmol/mL)1.98 (1.98)2.64 (6.92)
H2O2 (nmol/mL)
TBARS (μmol/mL)1.09 (0.11)1.12 (0.10)
NO2- (nmol/mL)
GSH (nmol/mL RBC ×103)
CAT (U/gHb ×103)1.75 (1.25)1.25 (1.19)
SOD (U/gHb ×103)
Values are shown as mean (SD), except for O2-, TBARS, and CAT, where data were not normally distributed and shown as median (interquartile range). . ERI, erythropoietin resistance index; O2-., superoxide anion radical; H2O2, hydrogen peroxide; TBARS, thiobarbituric acid reactive substances; NO2-, nitrites; GSH, reduced glutathione; RBC, red blood cells; CAT, catalase; SOD, superoxide dismutase, Hb, hemoglobin.