Oxidative Medicine and Cellular Longevity

Research Article

Erythropoietin Resistance Development in Hemodialysis Patients: The Role of Oxidative Stress

Table 2

Parameters of oxidative stress and resistance to long-acting erythropoietin: darbepoetin-α.
Measured parametersERI (IU/kg/week/gHb)Value
<0.005 μg/kg/week/gHb≥0.005 μg/kg/week/gHb
NonresistantResistant
O2-. (nmol/mL)1.32 (1.81)2.47 (5.68)
H2O2 (nmol/mL)
TBARS (μmol/mL)1.09 (0.11)1.08 (0.08)
NO2- (nmol/mL)
GSH (nmol/mL RBC ×103)
CAT (U/gHb ×103)
SOD (U/gHb ×103)
Values are shown as mean (SD), except for O2- and TBARS, where data were not normally distributed and shown as median (interquartile range).. ERI, erythropoietin resistance index; O2-., superoxide anion radical; H2O2, hydrogen peroxide; TBARS, thiobarbituric acid reactive substances; NO2-, nitrites; GSH, reduced glutathione; RBC, red blood cells; CAT, catalase; SOD, superoxide dismutase, Hb, hemoglobin.