IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo

<div>IL-22 can inhibit CoCl<sub>2</sub>-induced apoptosis of HIBEpiCs in vitro. (a) After treatment of CoCl<sub>2</sub> alone and CoCl<sub>2</sub>+IL-22 combined treatment of HIBEpiCs for 24, 48, and 72 hours, the apoptosis level was detected by flow cytometry. IL-22 could significantly reduce the apoptosis level of HIBEpiCs at 48 and 72 hours. (b and c) Detection of apoptosis-related protein expression in different groups by Western blot assay. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 

Figure 4 | IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 