IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo

<div>The antioxidative stress effects of IL-22 on CoCl<sub>2</sub>-induced HIBEpiC injury in vitro. (a) IL-22 could increase SOD levels and decrease MDA levels compared with the CoCl<sub>2</sub> group. (b) Flow cytometry was used to detect the level of ROS in cells in each group. Compared with the CoCl<sub>2</sub> group, IL-22 could significantly reduce ROS levels. (c) IL-22 can reduce the degree of mitochondrial membrane depolarization induced by CoCl<sub>2</sub>. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 

Figure 5 | IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 