IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo

<div>In vivo validation that IL-22 reduces IRI-induced apoptosis by activating STAT3. (a) The expression of STAT3 and p-STAT3 after intraperitoneal injection of RcIL-22 in rats for 1, 2, and 6 hours. (b) RcIL-22 can reduce the expression of cleaved-caspase3 and BAX protein and increase the expression of BCL2 and BCLXL protein in rats compared with the IRI group. (c) Evaluation of TUNEL expression in rat bile duct tissue sections by immunofluorescence staining. 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Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 

Figure 8 | IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 