IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo

<div>RcIL-22 promotes bile duct cell proliferation, reduces bile duct injury, improves liver function, and reduces bile duct oxidative stress levels in vivo. (a) The expression of Ki67 in rat bile duct tissue sections was evaluated by immunofluorescence staining, and the expression of Ki67 was higher after RCIL-22 treatment than in the IRI group. (b and c) RcIL-22 reduces MDA levels and increases SOD levels in rat bile duct tissue. (d and e) RcIL-22 reduced AST, ALT, and TBIL levels compared with the IRI group. (f) RcIL-22 can reduce the histological injury of the bile duct in rats induced by IRI. 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Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 

Figure 9 | IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo 