[Retracted] Conservative Therapy vs. Endovascular Approach for Intracranial Vertebrobasilar Artery Trunk Large Aneurysms: A Prospective Multicenter Cohort Study
Table 3
Treatment and imaging outcomes of patients.
Characteristics
Endovascular group
Conservative group
RR (95% CI)
value
Number of patients with clinical FU
51
18
—
—
Median clinical FU (m) (IQR)
39.0 (9.0, 48.0)
19.5 (4.8, 38.3)
—
0.030
Overall SAEs, (%)
8 (15.7)
8 (44.4)
0.35 (0.16-0.80)
0.031
Death
1 (2.0)
7 (38.9)
0.05 (0.01-0.38)
<0.001
Ischemic stroke
7 (13.7)
3 (16.7)
0.82 (0.24-2.8)
1.000
Major stroke
4 (7.8)
2 (11.1)
Minor stroke
3 (5.9)
1 (5.6)
Hemorrhage
1 (2.0)
4 (22.2)
0.09 (0.01-0.74)
0.020
Others
2 (3.9)
1 (5.6)
0.71 (0.07-7.33)
1.000
SAEs within 30 d of enrollment, (%)
6 (11.8)
2 (11.1)
1.06 (0.24-4.78)
1.000
Death
0
2 (11.6)
0.07 (0.01-1.45)
0.065
Ischemic stroke
5 (9.8)
1 (5.6)
1.77 (0.22-14.11)
0.949
Major stroke
2 (3.9)
1 (5.6)
Minor stroke
3 (5.9)
0
Hemorrhage
1 (2.0)
1 (5.6)
0.35 (0.02-5.53)
0.457
SAEs 30 d after enrollment, (%)
4 (7.8)
6 (33.3)
0.24 (0.08-0.74)
0.024
Death
1 (2.0)
5 (27.8)
0.07 (0.01-0.56)
0.004
Ischemic stroke
2 (3.9)
2 (11.6)
0.35 (0.05-2.32)
0.592
Major stroke
2 (3.9)
1 (5.6)
Minor stroke
0
1(5.6)
Intracranial hemorrhage
1 (2.0)
3 (16.7)
0.12 (0.01-1.06)
0.086
Others
1 (2.0)
1 (5.6)
0.35 (0.02-5.35)
0.457
mRS at last follow-up, (%)
—
0.009
0-2
45 (88.2)
10 (55.6)
3-6
6 (11.8)
8 (44.4)
Number of patients with imaging FU
44
9
Median imaging FU (m) (IQR)
6.0 (6.0, 12.0)
12.0 (12.0, 22.0)
Aneurysm imaging finding, (%)
—
<0.001
Occluded
25 (56.8)
0
Improved
3 (6.8)
0
Stable
9 (20.5)
5 (55.6)
Recanalized
5 (11.4)
0
Enlarged
2 (4.5)
4 (44.4)
FU: follow-up; IQR: interquartile range; SAEs: serious adverse events; mRS: modified Rankin Scale. One patient experienced two intracranial hemorrhage events, one within 30 days of enrollment and one 30 days after enrollment. One patient experienced a minor stroke within 30 days and an SAE (gross hematuria) after 30 days. One patient had a major stroke within 30 days and a minor stroke after 30 days.
