Circular RNA_0057209 Acts as ceRNA to Inhibit Thyroid Cancer Progression by Promoting the STK4-Mediated Hippo Pathway via Sponging MicroRNA-183

Figure 1

circRNA_0057209 expression was reduced in thyroid cancer tissues and cells. (a) The expression of circRNA_0057209 in thyroid cancer tissues and adjacent normal tissues determined by qRT-PCR. . Compared with adjacent normal tissues, . (b) The expression of circRNA_0057209 in thyroid cancer tissues of thyroid cancer patients at different TNM stages ( for I-II stage and for III+IV stage). Compared with the I+II staging group, , , . (c) circRNA_0057209 expression in thyroid cancer tissues of thyroid cancer patients with different differentiation degrees ( for poor differentiation and for well and moderate differentiation). Compared with the poor differentiation group, , , . (d) circRNA_0057209 expression in 4 kinds of thyroid cancer cells and normal thyroid cells determined by qRT-PCR. Compared with NTHY-ORI3.1 cells, , , . (e) The amplification of circRNA_0057209 in cDNA and gDNA in TPC-1 and HTH83 cell lines determined by qRT-PCR. (f) mRNA abundance of circRNA_0057209 and linear 0057209 in TPC-1 and HTH83 cells treated with RNase R determined by qRT-PCR. Compared with the NC group, , , . The cell experiment was repeated three times independently.

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