Circular RNA_0057209 Acts as ceRNA to Inhibit Thyroid Cancer Progression by Promoting the STK4-Mediated Hippo Pathway via Sponging MicroRNA-183

Figure 2

Bioinformatics analysis predicted the differentially expressed circRNAs, miRNAs, and mRNAs and their molecular interactions in thyroid cancer. (a) A heat map of the expression of the top 10 differentially expressed circRNAs with the smallest value in the expression dataset GSE93522. The color scale from blue to red indicates that the expression value is from small to large. (b) circRNA_0057209 was lowly expressed in thyroid cancer. (c) Venn diagram of the miRNAs that bind to circRNA predicted by circBank and significantly upregulated miRNAs in the GSE40807 dataset. (d) hsa-miR-183 expression in thyroid cancer in the GSE40807 dataset. (e) The binding site between hsa_circ_0057209 and hsa-miR-183 predicted by CircInteractome. (f) Venn diagram of target genes of miRNA predicted by miRWalk and starBase and the significantly downregulated genes in the GSE65144 dataset. (g) Enrichment analysis results of candidate genes involved biological processes. (h) The binding site between hsa-miR-183 and STK4 predicted by starBase. (i) Correlation analysis between miR-183 and STK4 in thyroid cancer.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)