Circular RNA_0057209 Acts as ceRNA to Inhibit Thyroid Cancer Progression by Promoting the STK4-Mediated Hippo Pathway via Sponging MicroRNA-183

Figure 8

circRNA_0057209 arrested the tumorigenesis of thyroid cancer by regulating the miR-183/STK4 signaling. Nude mice were injected with TPC-1 cells transduced with lentivirus carrying oe-circRNA_0057209 or sh-STK4. (a) qRT-PCR and Western blot analyses showing the expression of circRNA_0057209, STK4 and miR-183, as well as YAP1 phosphorylation levels in tumor tissues of mice. (b) IHC results showing the YAP1 phosphorylation levels and STK4 protein expression in tumor tissues of mice (×200). (c) Representative macroscopic images of transplanted tumors in nude mice. (d) Quantification of tumor volume. (e) Weight of transplanted tumors in nude mice. Compared with compared with the oe-NC+sh-NC group, , ^# indicated that compared with the oe-circRNA_0057209_0057209+sh-NC group, , , ; ^##, ^###. for mice in each group. The cell experiment was repeated three times independently.

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