Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation

<div>Effects of the G3842A mutation on the protein structure. (a) Structures of proteins encoded by <i>NADH dehydrogenase subunit 1</i> (<i>ND1</i>) and <i>ND1</i> harboring the G3842A mutation were predicted using the SWISS-MODEL. (b) Transmembrane structures of proteins encoded by <i>ND1</i> and <i>ND1</i> harboring the G3842A mutation were obtained from TMHMM. NADH: nicotinamide adenine dinucleotide hydride.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2

Figure 2: Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation 