Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation

<div>The G3842A mutation significantly activates ERK1/2 signaling. (a) Analysis of DEGs using the KEGG pathway database after transcriptome sequencing of WT and MUT cells. Phosphorylation levels of members of the MAPK pathway, including (b) ERK1/2, (c) p38, and (d) JNK in WT cells and MUT cells, were examined using Western blotting. 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DEGs: differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: c-Jun N-terminal kinase.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation 