Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation

Figure 8

The G3842A mutation promotes tumor growth in vivo in a ROS-dependent manner. (a) Tumor xenograft experiments were performed by injecting nude mice with MUT cells or cells or WT cells or cells. Each mouse developed only one visible tumor at the injection site. (b) Tumor volume was monitored weekly, and (c) tumor weight was calculated on 35 days after injection for each group (/group). The first NAC injection (shown as the 0 week after injecting NAC in the graph) was performed 1 week after subcutaneous injection of the cells, with the tumor volume measured before NAC injection. We defined the mean tumor volume of six mice on day 0 of NAC injection as “1.” The tumor volume of each mouse on weeks 1 through 5 after NAC injection was compared with the mean tumor volume of six mice (in each group) on day 0 of NAC injection in order to present increasing trends in tumor volume for each group. All data are presented as . , , and .

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