Anlotinib Alleviates Renal Fibrosis via Inhibition of the ERK and AKT Signaling Pathways

<div>Anlotinib attenuated inflammatory responses in a UUO mouse model. (a) The mRNA expression of CCL2, CCL5, and IL-6 in the mouse kidneys was examined by real-time PCR. Quantitative RT-PCR showed increased mRNA expression of CCL2, CCL5, and IL-6 in UUO mice compared to the sham group. These markers of inflammation were reduced in the mice treated with anlotinib. (b, c) Immunochemical staining of CD163 and F4/80 in the kidney tissue of OUU mice. 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Oxidative Medicine and Cellular Longevity

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Figure 3

Figure 3: Anlotinib Alleviates Renal Fibrosis via Inhibition of the ERK and AKT Signaling Pathways 