[Retracted] Genetic Analysis Reveals Different Mechanisms of IL-5 Involved in the Development of CAD in a Chinese Han Population
Table 2
Allelic association analysis between IL5 and CAD.
Population
SNP allele
MAF
OR (95% CI)
Case
Control
Case
Control
Discovery
rs2057687T
667
729
0.087
0.134
0.793
0.035
0.68 (0.47-0.97)
rs78546665T
619
692
0.148
0.166
0.259
0.197
0.173
0.81 (0.59-1.10)
rs2069812G
742
745
0.285
0.313
0.224
0.099
0.519
0.93 (0.73-1.07)
Validation
rs2057687T
993
1023
0.123
0.119
0.050
0.690
0.661
1.05 (0.84-1.31)
rs78546665T
907
972
0.182
0.165
0.201
0.161
0.157
1.16 (0.95-1.41)
rs2069812G
1039
1017
0.302
0.301
0.020
0.953
0.860
0.99 (0.84-1.15)
Combined
rs2057687T
1660
1752
0.108
0.125
0.102
0.030
0.225
0.89 (0.74-1.07)
rs78546665T
1526
1664
0.168
0.166
0.806
0.760
0.674
1.04 (0.88-1.22)
rs2069812G
1781
1762
0.295
0.306
0.011
0.307
0.336
0.94 (0.83-1.07)
SNP: single nucleotide polymorphism; CAD: coronary artery disease; MAF: minor allele frequency; : observed value; , value adjusted by the covariates; age, sex, BMI, hypertension, diabetes mellitus, smoking history, Tch, TG, HDL-c, and LDL-c were adjusted; OR: odds ratio after adjustment; : value from the Hardy–Weinberg equilibrium tests.