RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by Activating PI3K/Akt Signaling Pathway

Figure 1

RNF7 is upregulated in PC tissues and demonstrated poor prognosis. (a) The level of RNF7 expression in different cancer tissues compared to normal tissues. (b) Box plots of SOX1 expression in PC tissues compared to normal bile duct tissues. Data sourced from GEPIA database. (c) Kaplan–Meier plot of overall survival of PC patients with RNF7 built on the GEPIA database. (d) RNF7 mRNA expression levels in normal pancreatic tissues and pancreatic cancer tissues. (e) RNF7 mRNA expression levels in normal pancreatic cell line and seven different established PC cell lines. (f) Kaplan–Meier analysis of the association of high- or low-RNF7 expression with overall survival in PC. (g) Representative immunohistochemical staining images of RNF7 expression in PC tissues and matched adjacent nontumor tissues () (scar bar: 50 μm). (h) Relative RNF7-expression levels in immunohistochemical staining analysis. Data appeared to be , , and .

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