Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia–Reperfusion Injury by Suppressing the I<i>κ</i>B<i>α</i>/NF-<i>κ</i>B/IL-17C Pathway

<div>RNA-seq results showed that ALDH2 deficiency led to changes in inflammatory molecular pathways. (a) The volcano plots showed the differential genes between the KO-IR and WT-IR groups. (b) Heat map showing mRNA differences in RNA-seq. (c) Expression of ALDH2, I<i>κ</i>B<i>α</i>, HSP90, Gldc, JUN, and S100a9 mRNA was determined by RT-qPCR. 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(d) KEGG enrichment analysis revealed the signal pathway of the concentrated expression of differential genes in the KO-IR and WT-IR groups.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia–Reperfusion Injury by Suppressing the I<i>κ</i>B<i>α</i>/NF-<i>κ</i>B/IL-17C Pathway 

Oxidative Medicine and Cellular Longevity

Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia–Reperfusion Injury by Suppressing the IκBα/NF-κB/IL-17C Pathway

Figure 2