The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior

<div>The gut microbiota mediated the effects of WZYD on CGRP, inflammatory factor, and c-Fos. (a, b) The protein expression of CGRP in TNC. (c) The content of CGRP in plasma. (d–f) The protein expressions of TNF-<i>α</i> and IL-1<i>β</i> in TNC. (g) The c-Fos positive cell in PAG by IF staining. (h) The c-Fos positive cell in TNC by IF staining. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior 