Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model

Figure 2

Effect of OST on ROS generation. (a) Production of intracellular ROS in each experimental group after 24 h of LPS and OST treatments. (b) Production of intracellular ROS in each experimental group after 48 h of RANKL and 25 μM OST treatments. (c, d) A multifunctional microplate reader was used to measure and calculate the fluorescence intensity of ROS in each experimental group. (e) Chemical structure of OST. (^#compared with the BMM group, compared with the M1 or RANKL group, ^###, , , ). Data are expressed as median and interquartile range, .

(a)

(b)

(c)

(d)

(e)