Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model

Figure 6

OST inhibited the RANKL-induced activation phosphorylation of NF-κB and P38/MAPK. (a) OST impaired the RANKL-induced phosphorylation of P65 and P38 but not of P-JNK and P-ERK. (b, c) Quantitative densitometric analysis of P-P65 and P-P38 phosphorylation normalized to the total P65 and P38 expression. (, , ). Data are expressed as median and interquartile range, .

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