Cardiovascular-Specific Mortality among Gastrointestinal Stromal Tumor Patients: A Population-Based Analysis
Table 1
Standardized mortality ratios of cardiovascular disease mortality among GIST patients according to baseline characteristics.
Characteristics
Total diagnosis1 (%)
CVD2
Observed deaths (%)
Expected deaths
SMR (95% CI)
Total
12058 (100.0)
477 (100.0)
147.48
3.23 (2.97-3.52)
Sex
Male
6268 (52.0)
251 (52.6)
71.55
3.51 (3.12-3.94)
Female
5790 (48.0)
226 (47.4)
75.93
2.98 (2.63-3.37)
Age at diagnosis
18-49
1961 (16.3)
7 (1.5)
0.44
15.91 (9.19-27.53)
50-64
4145 (34.4)
93 (19.5)
8.35
11.14 (9.48-13.09)
65-79
4495 (37.3)
201 (42.1)
58.22
3.45 (3.03-3.93)
≥80
1457 (12.0)
176 (36.7)
80.45
2.19 (1.89-2.53)
Race
White
8197 (68.0)
346 (72.5)
117.93
2.93 (2.65-3.24)
Black
2136 (17.7)
86 (18.0)
18.71
4.60 (3.79-5.57)
Other
1725 (14.3)
45 (9.4)
10.84
4.15 (3.17-5.43)
Marital status
Married
9475 (78.6)
388 (81.3)
129.98
2.99 (2.72-3.28)
Unmarried
1947 (16.1)
69 (14.5)
13.76
5.01 (4.06-6.20)
Unknown
636 (5.3)
20 (4.2)
3.74
5.35 (3.62-7.91)
Year of diagnosis
2000-2004
1965 (16.3)
147 (30.8)
63.69
2.31 (1.97-2.70)
2005-2009
2517 (20.9)
149 (31.2)
50.98
2.92 (2.51-3.41)
2010-2014
3497 (29.0)
132 (27.7)
27.98
4.72 (4.04-5.51)
2015-2019
4079 (33.8)
49 (10.3)
4.83
10.14 (8.09-12.72)
SEER stage
Local
5965 (49.5)
269 (56.4)
87.48
3.07 (2.75-3.44)
Regional
1337 (11.1)
61 (12.8)
26.28
2.32 (1.82-2.96)
Distant
1670 (13.8)
56 (11.7)
9.81
5.71 (4.53-7.20)
Unknown
3086 (25.6)
91 (19.1)
23.90
3.81 (3.15-4.61)
Primary site
Stomach
7126 (59.1)
284 (59.5)
95.03
2.99 (2.68-3.34)
Small intestine
3362 (27.9)
123 (25.8)
32.87
3.74 (3.17-4.41)
Rectum
318 (2.6)
12 (2.5)
2.69
4.46 (2.66-7.48)
Colon
292 (2.4)
12 (2.5)
6.85
1.75 (1.00-3.06)
Esophagus
70 (0.6)
2 (0.4)
0.41
4.91 (0.59-17.73)
Other
890 (7.4)
44 (9.2)
9.63
4.57 (3.49-5.98)
Surgery
Yes
9822 (81.5)
358 (75.1)
122.19
2.93 (2.65-3.23)
No
2139 (17.7)
115 (24.1)
23.94
4.80 (4.07-5.67)
Unknown
97 (0.8)
4 (0.8)
1.35
2.96 (1.17-7.54)
Chemotherapy
Yes
5088 (42.2)
138 (28.9)
28.96
4.77 (4.10-5.54)
No/unknown
6970 (57.8)
339 (71.1)
118.52
2.86 (2.58-3.17)
Radiotherapy
Yes
116 (1.0)
4 (0.8)
1.71
2.34 (0.64-5.98)
No/unknown
11942 (99.0)
473 (99.2)
145.77
3.24 (2.98-3.53)
1Database “SEER Research Plus Data, 17 Registries (excl AK), Nov 2021 Sub (2000-2019)” was used. 2Database “SEER Research Plus Data, 17 Registries (excl AK), Nov 2021 Sub (2000-2019) for SMRs” was used. Race: other (American Indians/AK Native and Asian/Pacific Islanders); primary site: other (appendix and peritoneum). Abbreviation: GIST: gastrointestinal stromal tumor; SMR: standardized mortality ratio; CI: confidence interval.
