Cardiovascular-Specific Mortality among Gastrointestinal Stromal Tumor Patients: A Population-Based Analysis

Table 3

Multivariate competing risk analysis for predictors of cardiovascular mortality in patients with GIST.

Characteristics	Adjusted HR	95% CI
Sex			<0.01
Male		Ref
Female	0.803	0.682-0.947
Age at diagnosis			<0.001
18-49		Ref
50-64	6.856	3.339-14.080	<0.001
65-79	17.403	8.605-35.195	<0.001
≥80	54.817	27.075-110.985	<0.001
Race			<0.01
White		Ref
Black	1.147	0.917-1.436	0.23
Other	0.622	0.462-0.838	<0.01
Marital status			0.019
Married		Ref
Unmarried	1.421	1.112-1.815	<0.01
Unknown	1.073	0.720-1.599	0.73
Year of diagnosis			<0.001
2000-2004		Ref
2005-2009	0.752	0.608-0.931	<0.01
2010-2014	0.587	0.470-0.733	<0.001
2015-2019	0.485	0.360-0.654	<0.001
SEER stage			0.069
Local		Ref
Regional	0.866	0.669-1.121	0.27
Distant	0.684	0.505-0.925	0.014
Unknown	1.040	0.784-1.378	0.79
Primary site			0.72
Stomach		Ref
Small intestine	1.120	0.922-1.360	0.26
Rectum	1.281	0.755-2.175	0.34
Colon	0.980	0.602-1.596	0.94
Esophagus	0.549	0.132-2.277	0.41
Other	0.987	0.677-1.438	0.94
Surgery			0.40
Yes		Ref
No	1.113	0.877-1.412	0.38
Unknown	1.551	0.714-3.371	0.27
Chemotherapy			0.02
Yes		Ref
No/unknown	1.272	1.039-1.557
Radiotherapy			0.44
Yes		Ref
No/unknown	1.469	0.551-3.913

Race: other (American Indians/AK Native and Asian/Pacific Islanders); primary site: other (appendix and peritoneum). Abbreviation: GIST: gastrointestinal stromal tumor; HR: hazard ratio; CI: confidence interval.