Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress

<div>Expression of LC-3I/II, p62, and Beclin1 in the testicular cells <i>in vivo</i> and <i>in vitro</i>. (a) The immunofluorescent staining of p62 and LC-3I/II in the testis of diabetic mice. Red arrow indicates Leydig cells. (b) Representative immunoblotting of LC-3I/II, p62, and Beclin1 in Sertoli cells. (c) Densitometric qualification of LC-3II, p62, and Beclin1 in Sertoli cells. (d) Representative immunoblotting of LC-3I/II, p62, and Beclin1 in Leydig cells. (e) Densitometric quantification of LC-3II, p62, and Beclin1 in Leydig cells. Diabetes exerts dual effects on autophagy regulation in Sertoli and Leydig cells. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress 