Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress

Figure 6

Activation of HIF-1α pathway in Sertoli cells of diabetic mice. (a) Representative immunoblotting of Akt and p-Akt in the testis of diabetic mice. (b) Densitometric qualification of Akt and p-Akt in the testis of diabetic mice. (c) Representative immunoblotting of p-P70S6K and HIF-1α in the testis of diabetic mice. (d) Densitometric qualification of p-P70S6K and HIF-1α in the testis of diabetic mice. (e) Representative immunoblotting of dimer and monomer BNIP3 in the testis of diabetic mice. (f) Densitometric qualification of dimer and monomer BNIP3 in the testis of diabetic mice. (g) Representative immunoblotting of dimer and monomer BNIP3 in the cytoplasm and mitochondrion. DM: diabetes mellitus. was considered to indicate a statistically significant difference. vs. Ctrl.

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