A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway

<div>Mep-S protects against H<sub>2</sub>O<sub>2</sub>-induced neurotoxicity in SH-SY5Y cells. (a) Chemical structure of Mep-S. Mep-S protected against H<sub>2</sub>O<sub>2</sub>-induced cell death (b) and LDH release (c) in SH-SY5Y cells. The cells were pretreated with Mep-S (0.5-5 <i>μ</i>M) or N-acetyl-L-cysteine (NAC, 1 mM) for 1 h prior to stimulation with H<sub>2</sub>O<sub>2</sub> (400 <i>μ</i>M) for 24 h. 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Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway 

Figure 1 | A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway 