A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway

<div>Mep-S protects against H<sub>2</sub>O<sub>2</sub>-induced neuronal apoptosis in SH-SY5Y cells. Mep-S inhibited H<sub>2</sub>O<sub>2</sub>-induced apoptosis (a) and loss of mitochondrial membrane potential (b) in SH-SY5Y cells. (c) Mep-S inhibited H<sub>2</sub>O<sub>2</sub>-induced upregulation of cleaved caspase-3 levels. The cells were pretreated with Mep-S (1 <i>μ</i>M) or NAC (1 mM) for 1 h and then exposed to H<sub>2</sub>O<sub>2</sub> (400 <i>μ</i>M) for another 24 h. 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Oxidative Medicine and Cellular Longevity

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Figure 2

Figure 2: A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway 

Figure 2 | A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway 