A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway

Figure 6

Mep-S attenuates neuronal apoptosis in the brains of scopolamine-treated mice. (a) Representative images of hematoxylin and eosin staining (upper panel) and quantitative analysis of the number of surviving neurons (lower panel) in the hippocampal CA1 and CA3 regions. Scale bar, 50 μm. One-way ANOVA: , (CA1); , (CA3). (b) Protein expression of Bcl-2 and Bax in the hippocampus and cerebral cortex of mice was determined by western blot analysis. One-way ANOVA: , (hippocampus); , (cortex). Data are presented as the ( per group). and .

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