A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway

Figure 8

Mep-S activates the Nrf2/antioxidant enzyme pathway in the brains of scopolamine-treated mice. (a) Protein levels of HO-1, NQO-1, Keap1, and phosphorylated Akt and Nrf2 in the hippocampus and cerebral cortex of mice detected by western blot analysis. Densitometric analysis of protein expression in the Nrf2/antioxidant enzyme pathway in the hippocampus (b) and cortex (c) of mice in the control, scopolamine-treated, and scopolamine+Mep-S-treated groups. One-way ANOVA for hippocampus: , (HO-1); , (NQO-1); , (Keap1); , (p-Akt); , (p-Nrf2); , (Nrf2). One-way ANOVA for cortex: , (HO-1); , (NQO-1); , (Keap1); , (p-Akt); , (p-Nrf2); , (Nrf2). Data are presented as the ( per group). and .

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