NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner

Figure 5

Myrislignan suppressed the progression of GBM in vivo. (a) Representative HE staining of mice brain sections indicated that myrislignan suppressed the growth of GBM. (b) Kaplan-Meier curves of mice survival. (c) The tumor-bearing brains were weighed. Relative weight of tumors in brain was estimated (DMSO/Myris groups—PBS groups). (d, e) Protein levels of p-p65, Slug, and SLC7A11 in mouse tumor were detected by western blot and quantified. The protein samples were extracted from tumor tissues in DMSO and Myris group of intracranial xenograft models. (f) Expression of p-p65, Slug, E-cadherin, and SLC7A11 was evaluated via IHC staining. Scale bar, 50 μm. ; ; .

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