NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner

Figure 7

Mechanistic model for ferroptosis induced by myrislignan in GBM. Through inhibiting the phosphorylation of p65 protein, myrislignan suppressed the NF-κB signaling pathway and regulated EMT-related genes including Slug, Snail1, and E-cadherin, eventually inhibiting EMT. Meanwhile, myrislignan depressed system xc − activity and induced lipid peroxidation via the Slug-SLC7A11 signaling pathway. Furthermore, myrislignan combined with RSL3 enhanced the ferroptosis via targeting SLC7A11 and GPX4, respectively, which also controlled the EMT status of GBM cells.