Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Figure 8

The effects of several doses of GSH-PMAA-EDV nanogel (5, 20, 40, and 250 μg/kg) on behavioral function. (a) Discrimination ratio as an output of novel object recognition test. (b) Tendency of the rats to choose one arm in 6 trials in T-maze test. (c) Choosing correct arm by rat in T-maze test. Values are expressed as the and were analyzed using one-way ANOVA followed by Bonferroni’s multiple comparison test (). , , and compared with the control group. ^#, ^##, and ^### compared with stroke rats ().

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