Expansion of Lymphocytes from Prostatic Adenocarcinoma and Adjacent Nonmalignant Tissue

Figure 2

A prominent population of CD4⁺ T cells are found in TILs from prostate tissues. (a) The proportion of CD4⁺, CD8⁺, and CD4⁻CD8⁻ cells in the CD3⁺ population is shown for the TIL culture expanded from each tissue specimen. nd, not done. (b) The proportion of CD4⁺ T cells was compared to CD8⁺ T cells in TIL cultures from malignant and nonmalignant tissues (Mann-Whitney, two-tailed). (c) The proportions of CD4⁺ T cells, CD8⁺ T cells, and CD4⁻CD8⁻ T cells were compared between malignant tissues and matched nonmalignant tissues (paired t-test, two-tailed).

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