Review Article
Importance of the Brain Angiotensin System in Parkinson’s Disease
Table 2
Ligand activation of the AT1, AT2, and AT4 receptor subtypes influence the following functions.
| | AT1 receptor subtype | | | Vasoconstriction | | | Aldosterone release | | | Vasopressin release | | | Cardiac hypertrophy | | | Fibrosis | | | Proliferation | | | Inflammation | | | Platelet aggregation | | | Oxidative stress | | | Endothelial disruption | |
| | AT2 receptor subtype | | | Vasodilation | | | Antifibrotic | | | Antiproliferative | | | Antihypertrophic | | | Antithrombotic | |
| | AT4 receptor subtype | | | Dendritic arborization | | | Changes in blood flow | | | Memory facilitation | | | Protection against seizures | | | Facilitates wound healing | |
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