Review Article
Metabotropic Glutamate Receptors for Parkinson's Disease Therapy
Table 1
Glutamatergic agents cited within the text with their pharmacological profile, main target/s, and mode of action.
| | Target | Agent | Pharmacological action |
| | AMPA receptor | GYKI-52466 | Noncompetitive antagonist | | GYKI-53405 | Noncompetitive antagonist | | NBQX | Competitive antagonist | | Perampanel | Noncompetitive antagonist |
| | AMPA/kainate receptor | Tezampanel (LY293558) | Competitive antagonist | | Talampanel (LY300164) | Noncompetitive antagonist |
| | AMPA/NMDA receptor | CPP | Competitive antagonist |
| | NMDA receptor | Amantadine | Noncompetitive antagonist | | APV | Competitive antagonist | | CGP-43487 | Competitive antagonist | | Ifenprodil | Noncompetitive antagonist | | PAMQX | Competitive antagonist | | Remacemide | Noncompetitive antagonist | | Traxoprodil | Noncompetitive antagonist |
| | mGlu1 receptor | EMQMCM | Noncompetitive antagonist |
| | mGlu2 receptor | LY379268 | Competitive agonist |
| | mGlu4 receptor | PHCCC | PAM | | ADX88178 | PAM | | VU0155041 | PAM |
| | mGlu4/mGlu5 receptor | SIB-1893 | PAM/noncompetitive antagonist |
| | mGlu5 receptor | Dipraglurant (ADX48621) | Noncompetitive antagonist | | Mavoglurant (AFQ056) | Noncompetitive antagonist | | MPEP | Noncompetitive antagonist | | MRZ-8676 | Noncompetitive antagonist | | MTEP | Noncompetitive antagonist |
| | mGlu7 receptor | AMN082 | PAM |
| | mGlu8 receptor | DCPG | Competitive agonist |
|
|
