Addenbrooke’s Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson’s Disease

Table 1

Patient characteristics (). Characteristics are described as median (min-max).

	Total ()	PD-NC ()	PD-MCI ()	PD-D ()	value	Post hoc values
						PD-NC; × PD-MCI	PD-MCI; × PD-D	PD-NC; × PD-D
Sex, males (%)	41 (59.4%)	13 (59.1%)	25 (67.6%)	3 (30.0%)	0.100
Age (years)	68 (49–86)	70 (51–86)	67 (49–81)	65 (54–82)	0.754
Education (years)	13 (9–18)	13 (12–18)	13 (9–18)	12 (9–18)	0.006	0.466	0.062	0.004
PD duration (years)	7 (1–22)	7 (3–21)	8 (1–18)	6 (2–22)	0.510
L-dopa dose (mg/day)	907 (0–2275)	1037 (0–2275)	931 (56–2108)	591 (160–1836)	0.042	0.870	0.158	0.044
UPDRS III	25 (3–55)	29 (5–49)	25 (5–55)	19 (3–52)	0.333
MMSE	29 (16–30)	29 (27–30)	29 (27–30)	25 (16–26)	<0.001	0.046	<0.001	<0.001
ACE-R	87 (60–99)	93 (80–98)	87 (72–99)	79 (60–87)	<0.001	0.001	0.020	<0.001
ACE-R AO	18 (13–18)	18 (17-18)	17 (15–18)	15 (13–18)	<0.001	0.130	<0.001	<0.001
ACE-R M	21 (3–26)	23 (17–26)	19 (12–26)	18 (3–21)	0.001	0.057	0.126	0.001
ACE-R F	11 (3–14)	13 (6–14)	10 (3–14)	9 (5–12)	0.001	0.005	0.782	0.004
ACE-R L	25 (20–26)	26 (24–26)	25 (20–26)	25 (21–26)	0.176
ACE-R VA	15 (10–16)	16 (13–16)	15 (12–16)	14 (10–16)	0.003	0.250	0.031	0.005

UPDRS III: Unified Parkinson’s Disease Rating Scale.
MMSE: Mini Mental State Examination.
ACE-R: Addenbrooke’s Cognitive Examination, global score.
ACE-R AO: Addenbrooke’s Cognitive Examination, domain attention and orientation.
ACE-R M: Addenbrooke’s Cognitive Examination, domain memory.
ACE-R F: Addenbrooke’s Cognitive Examination, domain verbal fluency.
ACE-R L: Addenbrooke’s Cognitive Examination, domain language.
ACE-R VA: Addenbrooke’s Cognitive Examination, domain visual spatial abilities.