Polymorphism in the Vesicular Monoamine Transporter 2 Gene Decreases the Risk of Parkinson’s Disease in Han Chinese Men

Table 2

Distribution of genotypes and alleles at rs363371 and rs363324 among Han Chinese with Parkinson’s disease (PD) and healthy controls.

	PD	Controls	OR, 95% CI,	OR, 95% CI,
rs363371
Genotype frequencies
AA	166 (29.6)	148 (30.1)	—	—
AG	284 (50.6)	255 (51.9)	1.135, 0.794–1.621, 0.487	1.145, 0.798–1.643, 0.462
GG	111 (19.8)	88 (17.9)	1.147, 0.827–1.590, 0.411	1.149, 0.826–1.598, 0.409
Dominant model
AA	166 (29.6)	148 (30.1)	—	—
AG + GG	395 (70.4)	343 (69.9)	1.027, 0.788–1.338, 0.845	1.034, 0.791–1.352, 0.804
Recessive model
AA + AG	450 (80.2)	403 (82.1)	—	—
GG	111 (19.8)	88 (17.9)	1.142, 0.838–1.557, 0.400	1.148, 0.839–1.570, 0.389
Allele frequencies
A	616 (54.9)	551 (56.1)	—	—
G	506 (45.1)	431 (43.9)	0.949, 0.828–1.088, 0.452	0.949, 0.827–1.090, 0.459
rs363324
Genotype frequencies
AA	21 (3.7)	19 (3.9)	—	—
AG	206 (36.7)	164 (33.6)	0.994, 0.524–1.885, 0.985	0.937, 0.490–1.791, 0.844
GG	334 (59.5)	304 (62.4)	0.875, 0.676–1.131, 0.308	0.865, 0.666–1.123, 0.275
Dominant model
AA	21 (3.7)	19 (3.9)	—	—
AG + GG	540 (96.3)	468 (96.1)	1.044, 0.554–1.966, 0.894	0.989, 0.521–1.876, 0.972
Recessive model
AA + AG	227 (40.5)	283 (74.1)	—	—
GG	334 (59.5)	304 (25.9)	0.886, 0.690–1.136, 0.340	0.872, 0.677–1.122, 0.287
Allele frequencies
A	248 (22.1)	202 (20.7)	—	—
G	874 (77.9)	772 (79.3)	1.084, 0.893–1.317, 0.413	1.105, 0.907–1.344, 0.321

PD: Parkinson’s disease; CI: confidence interval; OR: odds ratio.
value for binary logistic regression after adjusting for age and gender.