Polymorphism in the Vesicular Monoamine Transporter 2 Gene Decreases the Risk of Parkinson’s Disease in Han Chinese Men

Table 3

Distribution of genotype and alleles at rs363371 in Han Chinese PD patients and controls, stratified by gender.

	PD	HC	OR, 95% CI,	OR, 95% CI,
Males
Genotype frequency
AA	72 (23.8)	87 (30.1)	—	—
AG	159 (52.6)	152 (52.6)	0.835, 0.571–1.221, 0.352	0.807, 0.549–1.187, 0.276
GG	71 (23.3)	50 (17.3)	0.615, 0.383–0.989, 0.045	0.594, 0.367–0.962, 0.034
Dominant model
AA	72 (23.8)	87 (27.4)	—	—
AA + AG	230 (76.2)	202 (72.6)	0.767, 0.535–1.101, 0.767	0.741, 0.514–1.070, 0.110
Recessive model
AA + AG	231 (76.5)	239 (82.7)	—	—
GG	71 (23.5)	50 (17.3)	0.692, 0.462–1.037, 0.075	0.684, 0.454–1.030, 0.069
Allele
A	303 (50.2)	326 (56.4)	—	—
G	301 (49.8)	252 (43.6)	0.799, 0.665–0.959, 0.016	0.785, 0.652–0.945, 0.011
Females
Genotype frequency
AA	94 (36.3)	61 (30.2)	—	—
AG	125 (48.3)	103 (51)	0.713, 0.472–1.079, 0.110	0.691, 0.456–1.048, 0.082
GG	40 (15.4)	38 (18.8)	0.874, 0.637–1.199, 0.405	0.871, 0.634–1.196, 0.393
Dominant model
AA	94 (36.3)	61 (30.2)	—	—
AG + GG	165 (63.7)	141 (69.8)	1.252, 0.844–1.857, 0.264	1.290, 0.897–1.856, 0.170
Recessive model
AA + AG	219 (84.6)	164 (81.2)	—	—
GG	40 (15.4)	38 (18.8)	1.164, 0.871–1.555, 0.305	1.185, 0.885–1.586, 0.256
Allele
A	311 (60.4)	225 (55.7)	—	—
G	205 (39.6)	179 (44.3)	0.844, 0.685–1.035, 0.108	0.829, 0.673–1.022, 0.079

PD: Parkinson’s disease; HC: healthy controls; CI: confidence interval; OR: odds ratio.
value for binary logistic regression after adjusting for age.