Polymorphism in the Vesicular Monoamine Transporter 2 Gene Decreases the Risk of Parkinson’s Disease in Han Chinese Men

Table 4

Distribution of genotype and alleles at rs363324 among Han Chinese PD patients and controls, stratified by gender.

	PD	HC	OR, 95% CI,	OR, 95% CI,
Males
Genotype frequency
AA	12 (4)	12 (4.2)	—	—
AG	121 (40)	98 (34.1)	0.855, 0.395–1.983, 0.766	0.914, 0.403–2.072, 0.829
GG	169 (56)	177 (61.7)	1.135, 0.513–2.510, 0.755	1.198, 0.535–2.682, 0.660
Dominant model
AA	12 (4)	12 (4.2)	—	—
AA + AG	290 (96)	275 (95.8)	1.031, 0.466–2.279, 0.940	1.078, 0.482–2.410, 0.855
Recessive model
AA + AG	133 (44)	110 (38.3)	—	—
GG	169 (56)	177 (61.7)	1.266, 0.957–1.676, 0.099	1.300, 0.978–1.729, 0.071
Allele
A	145 (24)	122 (21.3)	—	—
G	459 (76)	452 (78.7)	1.181, 0.918–1.519, 0.195	1.208, 0.936–1.560, 0.147
Females
Genotype frequency
AA	9 (3.5)	7 (3.5)	—	—
AG	85 (32.8)	66 (33)	0.877, 0.310–2.480, 0.805	0.920, 0.323–2.619, 0.876
GG	165 (63.7)	127 (63.5)	0.880, 0.316–2.447, 0.806	0.907, 0.324–2.539, 0.907
Dominant model
AA	9 (3.5)	7 (3.5)	—	—
AG + GG	250 (96.5)	193 (96.5)	0.879, 0.316–2.444, 0.804	0.912, 0.326–2.554, 0.861
Recessive model
AA + AG	94 (36.3)	73 (36.5)	—	—
GG	165 (63.7)	127 (63.5)	0.991, 0.769–1.278, 0.945	0.979, 0.758–1.246, 0.868
Allele
A	103 (19.9)	80 (20)	—	—
G	415 (80.1)	320 (80)	0.981, 0.723–1.330, 0.901	0.975, 0.718–1.325, 0.975

PD: Parkinson’s disease; HC: healthy controls; CI: confidence interval; OR: odds ratio.
value for binary logistic regression after adjusting for age.