Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation

Figure 3

The effect of M. communis on the permeability and toxicity of α-Syn. α-Syn was incubated for different times in the presence (, black) and absence (●, gray) of M. communis (1% v/v). (a) The calcein release from DOPG vesicles after adding α-Syn aggregates formed over 4 and 24 h. (b) The viability of the SH-SY5Y cells after 48 h incubation with α-Syn aggregated forms over different time (0–24 h). Each value represents the mean ± SD (). (Student’s t-test) indicated the samples are significantly different from the control. Controls are the viability of the SH-SY5Y cells treated with buffers.

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