LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson’s Disease Patients with Wearing Off: A Prospective, Open-Label Study

Table 2

Outcome measures from baseline to 12 weeks.

	Baseline	4 weeks	8 weeks	12 weeks
UPDRS II (off)	14.5 [10.8–18.2]	13.0 [9.0–15.3]	14.0 [7.0–15.8]	12.5 [8.3–16.0]
UPDRS II (on)	0.5 [0–2.5]	0 [0–1.3]	0 [0–1.5]	0.5 [0–2.3]
UPDRS III (on)	12.5 [8.8–15.5]	8.5 [6.5–11.5]	8.0 [6.0–11.0]	9.5 [7.8–13.3]
Daily off time (hours)	5.0 [4.4–5.2]	3.2 [1.8–3.6]	3.7 [2.8–4.3]	3.8 [3.5–4.6]
TUG (sec)	7.8 [7.3–8.1]	6.7 [5.9–7.4]	7.5 [6.4–8.9]	7.0 [6.6–8.2]
Timed 10 m (sec)	8.7 [7.4–9.7]	8.3 [7.3–9.1]	8.0 [7.0–8.5]	8.2 [8.0–8.4]

Data are median [interquartile range]. Baseline versus 12 weeks: ; baseline versus 4 weeks: .
UPDRS- III, Unified Parkinson’s Disease Rating Scale part III; TUG, Timed Up and Go.